Hmm. It sounds like you're being a little slippery between two slightly different ideas. Someone can be uninterested in a topic without thereby being unwelcoming or exclusionary about the topic.
So for instance, I have absolutely no interest in most professional sports. If someone is wearing a t-shirt with a football team on it, I am exceedingly unlikely to ask them about it, because I don't find sports interesting. I do not, however, think there is anything wrong with them for liking sports. I don't think there's anything wrong with their wearing that t-shirt. And I may end up liking them very much despite finding that particular aspect of their interests not particularly captivating.
I don't think it's necessary for friends to share all of the same interests. (Which is good, because I'd have basically no friends if I expected that - almost no one in SF fandom reads as broadly as I do in mainstream literature and the classics; I'd be screwed if I required that similarity to be friends.) So if no one is biting based on that t-shirt, maybe you won't find a connection based on that one interest. So try another - you say you have lots. Or try approaching them and asking about their interests. If you show interest in them, they may show interest in you. It sounds like you are taking the lack of shared interest in this one topic to mean that they won't want to know about any of your other interests; that just seems like a hasty generalization.
(And once they get to know you, they may want to hear more about that interest too. For instance, I'll listen to Roper talk about baseball FAR more than other people because I like him and I've started to see why he finds it interesting. I wouldn't have likely paid much attention to a stranger doing it, but once I have a connection with a person, I find their interests more interesting. I won't necessarily develop a huge interest myself, but I might at least want to find out something more.)
So I wouldn't give up - it's easy to take this perceived lack of interest as meaning that you'll never find people with commonalities, but that's not true. You just may need a different approach!
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So for instance, I have absolutely no interest in most professional sports. If someone is wearing a t-shirt with a football team on it, I am exceedingly unlikely to ask them about it, because I don't find sports interesting. I do not, however, think there is anything wrong with them for liking sports. I don't think there's anything wrong with their wearing that t-shirt. And I may end up liking them very much despite finding that particular aspect of their interests not particularly captivating.
I don't think it's necessary for friends to share all of the same interests. (Which is good, because I'd have basically no friends if I expected that - almost no one in SF fandom reads as broadly as I do in mainstream literature and the classics; I'd be screwed if I required that similarity to be friends.) So if no one is biting based on that t-shirt, maybe you won't find a connection based on that one interest. So try another - you say you have lots. Or try approaching them and asking about their interests. If you show interest in them, they may show interest in you. It sounds like you are taking the lack of shared interest in this one topic to mean that they won't want to know about any of your other interests; that just seems like a hasty generalization.
(And once they get to know you, they may want to hear more about that interest too. For instance, I'll listen to Roper talk about baseball FAR more than other people because I like him and I've started to see why he finds it interesting. I wouldn't have likely paid much attention to a stranger doing it, but once I have a connection with a person, I find their interests more interesting. I won't necessarily develop a huge interest myself, but I might at least want to find out something more.)
So I wouldn't give up - it's easy to take this perceived lack of interest as meaning that you'll never find people with commonalities, but that's not true. You just may need a different approach!